s10g_2.11.1

TRNA (guanine10-N2)-methyltransferase (EC 2.1.1.214, (m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine10 in tRNA



⇌


{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNAtRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.

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