Yes, but yong HDD na nakasalpak gamit ang USB will become Portable Storage Device (eg. USB Flashdrive) usually can still use as storage but not for the OS even if possible but not suggested.
Bili ka nalang ng boss ng hdd enclosure kung 2.5 lang hdd mo. Kung 3.5 naman enclosure na may sariling power supply. Or yung hdd docking bay. Kaso parang external hdd lang din siya.