Genres: s†éálth game, Action-adventure game, Puzzle, Shooter game
Six months following the events of the first game, siblings Amicia and Hugo de Rune, along with their mother Beatrice and her apprentice Lucas , seek refuge among an organization of alchemists called the Order. A hostile group of beekeepers attacks the siblings, causing the Prima Macula to reawaken in Hugo. In a town in Provence, Beatrice and Order representative Vaudin's attempts to treat Hugo only exacerbate his condition, resulting in the town being swarmed by rats and left in ruins. Vaudin is killed while the others escape on a boat bound for the Order's headquarters in Marseille.
Unwilling to see Hugo locked up as the Order’s test subject, Amicia takes Hugo and leaves Beatrice and Lucas to seek an island of which Hugo has recurring dreams, hoping it will lead to a cure for the Macula. Along the way, they are pursued by Provence soldiers, as well as mercenaries led by the disgraced knight Arnaud . Arnaud offers to arrange transport to the island from Hugo's dreams, La Cuna. They sail to the island on the ship of Arnaud's smuggler friend Sophia.